The Science

While our motivation is simple, the science that goes into creating a lung surfactant that resembles the real thing is a little more complicated.

Infasurf® (calfactant) has lower surface viscosity.1

The presence of cholesterol induces low surface viscosity which aids the spreading of surfactant film during respiration.

Cholesterol in Surfactant

Cholesterol contributes to the rapid spreading of native lung surfactant1

The lavage manufacturing process retains natural cholesterol in Infasurf® (calfactant)2

Infasurf® (calfactant) is the only surfactant available in the U.S. that contains a natural cholesterol level1

Impact of Cholesterol on Viscosity1

Surface Viscosity at 25ºC and Equilibrium Surface Tension ~23 mN/m

Recalculated and Redrawn from Kim K, et al., 2013

*(%, g/g of total lipid)

  • Native pig lung surfactant and Infasurf® (calfactant) contain the same level of cholesterol
  • Cholesterol is removed from Survanta® (beractant) and Curosurf® (poractant alfa), which are produced by a minced lung manufacturing process

There are no prospective, randomized clinical trials comparing Infasurf® and Curosurf® with respect to safety or efficacy.