While our motivation is simple, the science that goes into creating a lung surfactant that resembles the real thing is a little more complicated.
Infasurf® (calfactant) has lower dynamic viscosity.1
Low resistance to flow (dynamic viscosity) may improve the uniformity of distribution in the lung.
Dynamic Viscosities of Lung Surfactants1
Curosurf® (poractant alfa)
Changes in dynamic viscosity with temperature measured by comparing force necessary to produce a constant flow through a conduit.
- Low dynamic viscosity may impact ease of flow down the trachea and distal airways
- Infasurf® (calfactant) has the lowest dynamic viscosity at all temperatures
- Temperature changes vary dynamic viscosity only slightly for all surfactants
Approximate Dynamic Viscosities of Common Substances2,3
There are no prospective, randomized clinical trials comparing Infasurf® and Curosurf® with respect to safety or efficacy.