The Science

While our motivation is simple, the science that goes into creating a lung surfactant that resembles the real thing is a little more complicated.

Infasurf® (calfactant) has lower dynamic viscosity.1

Low resistance to flow (dynamic viscosity) may improve the uniformity of distribution in the lung.

Dynamic Viscosities of Lung Surfactants1

Normal Saline

Infasurf® (calfactant)

Curosurf® (poractant alfa)

Survanta® (beractant)

Changes in dynamic viscosity with temperature measured by comparing force necessary to produce a constant flow through a conduit.

  • Low dynamic viscosity may impact ease of flow down the trachea and distal airways
  • Infasurf® (calfactant) has the lowest dynamic viscosity at all temperatures
  • Temperature changes vary dynamic viscosity only slightly for all surfactants

Approximate Dynamic Viscosities of Common Substances2,3

There are no prospective, randomized clinical trials comparing Infasurf® and Curosurf® with respect to safety or efficacy.